Hemophilia is a blood disorder, which is genetically inherited. It is characterized by abnormal bleeding from the body. For a person to suffer from Hemophilia he or she must be having one or more abnormal genes inherited from parents especially the mother.
Inheritance
The defective gene is transferred from parent to the child in the form of a cell. This cell does not contain any instructions either negative or positive, concerned with the performance of certain functions in the blood such as making clotting factors 8 and 9. If it causes these, they might be generated incorrectly and this may lead to the development of Hemophilia. In human beings, genes occur in cells normally referred to as chromosomes. A human cell has twenty three pairs of chromosomes that occur in pairs in which half are from the father while the other is from the mother.
Genetics
One pair of sex chromosome determines sexual attributes among others. There are two types of sex chromosomes, Y and X chromosomes. Thus, fathers (males) have X and Y chromosomes while mothers (females) have two pairs of Xchromosomes. The X chromosomes are those that contain genes that generate clotting factors and this means that males are more likely to develop Hemophilia than females. A female can inherit one X chromosome, which is defective and she may not inherit two chromosomes that are defective. The normal X chromosome that she has will have the correct instruction used in the generation of clotting factors and this prevents them from inheriting Hemophilia. However, since males have only one X chromosome, if they happen to inherit a defective chromosome, it means that they will not have any normal X chromosomes to compensate for the defective one.
Spontaneous Gene Mutation
The cells then will carry incorrect instruction for the generation of clotting factors and hence, males are more likely to develop Hemophilia. Generally, Hemophilia can be said to be a disorder for males although the disorder affects females occasionally. Even if females may have one defective X chromosome, they will display the disorder, but they will be able to pass it to their children. Females that have a defective chromosome are just carriers of the disorder. Another cause of Hemophilia is spontaneous gene mutation. Family members with Hemophilia A or B are the first in their families to display the disorder. This occurs because during their early childhood development, random genetic reactions caused defects in their X chromosomes.
Hemophilia is a blood disorder, which is genetically inherited. It is characterized by abnormal bleeding from the body. For a person to suffer from Hemophilia he or she must be having one or more abnormal genes inherited from parents especially the mother.
Inheritance
The defective gene is transferred from parent to the child in the form of a cell. This cell does not contain any instructions either negative or positive, concerned with the performance of certain functions in the blood such as making clotting factors 8 and 9. If it causes these, they might be generated incorrectly and this may lead to the development of Hemophilia. In human beings, genes occur in cells normally referred to as chromosomes. A human cell has twenty three pairs of chromosomes that occur in pairs in which half are from the father while the other is from the mother.
Genetics
One pair of sex chromosome determines sexual attributes among others. There are two types of sex chromosomes, Y and X chromosomes. Thus, fathers (males) have X and Y chromosomes while mothers (females) have two pairs of Xchromosomes. The X chromosomes are those that contain genes that generate clotting factors and this means that males are more likely to develop Hemophilia than females. A female can inherit one X chromosome, which is defective and she may not inherit two chromosomes that are defective. The normal X chromosome that she has will have the correct instruction used in the generation of clotting factors and this prevents them from inheriting Hemophilia. However, since males have only one X chromosome, if they happen to inherit a defective chromosome, it means that they will not have any normal X chromosomes to compensate for the defective one.
Spontaneous Gene Mutation
The cells then will carry incorrect instruction for the generation of clotting factors and hence, males are more likely to develop Hemophilia. Generally, Hemophilia can be said to be a disorder for males although the disorder affects females occasionally. Even if females may have one defective X chromosome, they will display the disorder, but they will be able to pass it to their children. Females that have a defective chromosome are just carriers of the disorder. Another cause of Hemophilia is spontaneous gene mutation. Family members with Hemophilia A or B are the first in their families to display the disorder. This occurs because during their early childhood development, random genetic reactions caused defects in their X chromosomes.
